Title

Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction

Document Type

Article

Peer Reviewed

1

Publication Date

1-1-2008

Journal/Book/Conference Title

Journal of Chromatography A

Volume

1214

Abstract

A pressurized liquid extraction-based method for the simultaneous extraction and in situ clean-up of polychlorinated biphenyls (PCBs), hydroxylated (OH)-PCBs and methylsulfonyl (MeSO2)-PCBs from small (0.5 g) tissue samples was developed and validated. Extraction of a laboratory reference material with hexane-dichloromethane-methanol (48:43:9, v/v) and Florisil as fat retainer allowed an efficient recovery of PCBs (78-112%; RSD: 13-37%), OH-PCBs (46 2%; RSD: 4%) and MeSO2-PCBs (89 21%; RSD: 24%). Comparable results were obtained with an established analysis method for PCBs, OH-PCBs and MeSO2-PCBs. 2008 Elsevier B.V. All rights reserved.

Keywords

Sustainability, A pressurized liquid extraction-based method for the simultaneous extraction and in situ clean-up of polychlorinated biphenyls (PCBs), hydroxylated (OH)-PCBs and methylsulfonyl (MeSO2)-PCBs from small (0.5 g) tissue samples was developed and validated. Extraction of a laboratory reference material with hexane-dichloromethane-methanol (48:43:9, v/v) and Florisil as fat retainer allowed an efficient recovery of PCBs (78-112%, RSD: 13-37%), OH-PCBs (46 2%, RSD: 4%) and MeSO2-PCBs (89 21%, RSD: 24%). Comparable results were obtained with an established analysis method for PCBs, OH-PCBs and MeSO2-PCBs. 2008 Elsevier B.V. All rights reserved.

Published Article/Book Citation

Journal of Chromatography A, 1214:2011-01-02T00:00:00 (2008) pp.37-46.



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URL

http://ir.uiowa.edu/cee_pubs/29