Document Type

Article

Peer Reviewed

1

Publication Date

4-1-2015

NLM Title Abbreviation

J Oral Microbiol

Journal/Book/Conference Title

Journal of Oral Microbiology

PubMed ID

25840611

DOI of Published Version

10.3402/jom.v7.27182

Total Pages

12

Abstract

BACKGROUND: Severe-early childhood caries (S-ECC) is one of the most common infectious diseases in children and is prevalent in lower socio-economic populations. American Indian children suffer from the highest levels of S-ECC in the United States. Members of the mutans streptococci, Streptococcus mutans, in particular, are key etiologic agents in the development of caries. Children typically acquire S. mutans from their mothers and early acquisition is often associated with higher levels of tooth decay.

METHODS: We have conducted a 5-year birth cohort study with a Northern Plains Tribe to determine the temporality and fidelity of S. mutans transmission from mother to child in addition to the genotypic diversity of S. mutans in this community. Plaque samples were collected from 239 mother/child dyads at regular intervals from birth to 36 months and S. mutans were isolated and genotyped by arbitrarily primed-polymerase chain reaction (AP-PCR).

RESULTS: Here we present preliminary findings from a subset of the cohort. The focus for this paper is on initial acquisition events in the children. We identified 17 unique genotypes in 711 S. mutans isolates in our subset of 40 children, 40 mothers and 14 primary caregivers. Twelve of these genotypes were identified in more than one individual. S. mutans colonization occurred by 16 months in 57.5% of the children and early colonization was associated with higher decayed, missing and filled surface (DMFS) scores (p=0.0007). Children colonized by S. mutans shared a common genotype with their mothers 47.8% of the time. While multiple genotypes were common in adults, only 10% of children harbored multiple genotypes.

CONCLUSION: These children acquire S. mutans at an earlier age than the originally described 'window of infectivity' and often, but not exclusively, from their mothers. Early acquisition is associated with both the caries status of the children and the mothers.

Keywords

OAfund, caries, etiologic agents, American Indian, children, Streptococcus mutans, genotypic diversity, genotypes, oral microbiology, severe early childhood caries

Granting or Sponsoring Agency

NIH. NIH/NIDCR Institutional Training Program in Oral Health Research

Grant Number

R01-DE017736; T90-DE023520

Journal Article Version

Version of Record

Published Article/Book Citation

Journal of Oral Microbiology, 7:1, 27182, DOI: 10.3402/jom.v7.27182

https://doi.org/10.3402/jom.v7.27182

Rights

Copyright © 2015 David J Lynch et al

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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URL

http://ir.uiowa.edu/dentistry-pediatric_pubs/2