Document Type

Thesis

Date of Degree

Summer 2014

Degree Name

MS (Master of Science)

Degree In

Biomedical Engineering

First Advisor

Terry A. Braun

Abstract

Cordova (Curated Online Reference Database Of Variation Annotations) is an out-of-the-box solution for building and maintaining an online database of genetic variations integrated with population study information and pathogenicity prediction results from popular algorithms. Our primary motivation for developing this system is to aid researchers and clinician-scientists in determining the clinical significance of genetic variations. To achieve this goal, Cordova provides an interface to review and manually or computationally curate genetic variation data as well as share it for clinical diagnostics and the advancement of research.

Keywords

Annotation, Databases, Prediction, SNPs, Web services

Pages

vii, 63 pages

Bibliography

Includes bibliographical references (pages 60-63).

Copyright

Copyright 2014 Sean Ephraim

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