Document Type

Thesis

Date of Degree

2013

Degree Name

MS (Master of Science)

Degree In

Interdisciplinary Studies in Immunology

First Advisor

Siegfried Janz

Abstract

Three potential driver genes were identified by use of retroviral mutagenesis in the newly developed iMyc model of B cell malignancy. To do so, iMyc mice, which bear an inserted copy of c-Myc in the IgH locus, were treated with MOL4070LTR to favor the development of B cell malignancies. After tumor development, B cell origin tumors were identified by use of immunohistochemistry and selected for downstream analysis. Three genes were chosen as potential driver genes and validated in mouse or human disease as involved in disease or directly in malignancy. These genes are CD82, IRAK2 and DNMT3a.

Pages

vi, 83 pages

Bibliography

Includes bibliographical references (pages 77-83).

Copyright

Copyright 2013 Samuel Lifton

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