Document Type

Thesis

Date of Degree

Spring 2017

Degree Name

MS (Master of Science)

Degree In

Mechanical Engineering

First Advisor

Junyi Xia

Abstract

Intraoperative radiation therapy (IORT) involves delivering high doses of radiation directly to tumors while sparing healthy tissues in a surgical setting. Current IORT systems lack the capability to deliver conformal radiation therapy. To overcome the limitations of non-conformal radiation therapy a collimation system is needed to conform the radiation beam to the shape of the tumor. This work presents the development of a compact collimator design intended for a scanning beam IORT (SBIORT) system. The SBIORT collimator design enables the delivery of variable square doses to the targeted region within the surgical cavity. The SBIORT collimator has a compact circular footprint of 66 mm diameter and 10 mm thickness, with a maximum aperture of 20 mm. SBIORT collimator was prototyped to validate the design in positional accuracy and dosimetry experiments. Accuracy of the collimator leaf position was ±0.25mm at a 95% confidence interval. Dosimetric evaluation revealed the collimator to have a penumbra of 1.9 mm with a leaf transmission of 0.5%. The results support the feasibility of implementing the compact SBIORT collimator design in IORT.

Pages

vii, 46 pages

Bibliography

Includes bibliographical references (pages 44-46).

Copyright

Copyright © 2017 Brennen Neal Wears

Share

COinS