Document Type

Thesis

Date of Degree

Summer 2010

Degree Name

MS (Master of Science)

Degree In

Oral Science

First Advisor

Kim A. Brogden

Abstract

Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.

Keywords

alpha-defensins, beta-defensins, Periodontal Disease, periodontitis, Porphyromonas gingivalis

Pages

x, 99 pages

Bibliography

Includes bibliographical references (pages 55-65).

Copyright

Copyright 2010 Matthew David Carlisle

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