Title
Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis
Date of Degree
2010
Document Type
thesis
Degree Name
MS (Master of Science)
Department
Oral Science
First Advisor
Kim A. Brogden
Abstract
Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.
Pages
x, 99
Bibliography
55-65
Copyright
Copyright 2010 Matthew David Carlisle
Recommended Citation
Carlisle, Matthew David. "Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis." thesis, University of Iowa, 2010.
http://ir.uiowa.edu/etd/651.