Poster Title (Current Submission)

Applications of Functionalized Zeolites in Molecular Imaging

Major(s)

Anthropology, Chemistry

Minor(s)

French

Mentor Name

Dr. Sarah C. Larsen

Mentor Department

Chemistry

Abstract

Zeolites are porous, aluminosilicate materials. The adsorbent and ion-exchange capabilities of zeolites make them ideal candidates for carrying a wide variety of conventional and novel ionic metal MRI contrast agents (for example Gadolinium (III)) and positron-emitting radionuclides into the body (for example Gallium-68 (III)) for Magnetic Resonance Imaging (MRI) and positron-emission tomography (PET). Surface functionalization by trialkoxysilane condensation, followed by functional group modification by Huisgen azide-alkyne 1,3-cycloaddition, is explored as a means to add biologically selective moieties to the particle surfaces, thus facilitating concentration at points of interest in the body. A variety of synthetic pathways are demonstrated, along with pre- and post-synthesis loading of the ionic species. Special attention is paid to amount surface density of functional groups from different synthetic conditions. Multifunctional capabilities of zeolites open a flood of possibilities for these particles, extending beyond MRI and PET, and into other medical applications, such as fluorescent imaging, drug delivery, and heat therapy. The materials were characterized by BET (Brunauer-Emmett-Teller) surface area measurements, FTIR (Fourier-transformed infrared) spectroscopy, TGA (thermogravimetric analysis), 1H NMR (nuclear magnetic resonance) spectroscopy, and ICP-OES (inductively coupled plasma optical emission spectrometry).

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Applications of Functionalized Zeolites in Molecular Imaging

Zeolites are porous, aluminosilicate materials. The adsorbent and ion-exchange capabilities of zeolites make them ideal candidates for carrying a wide variety of conventional and novel ionic metal MRI contrast agents (for example Gadolinium (III)) and positron-emitting radionuclides into the body (for example Gallium-68 (III)) for Magnetic Resonance Imaging (MRI) and positron-emission tomography (PET). Surface functionalization by trialkoxysilane condensation, followed by functional group modification by Huisgen azide-alkyne 1,3-cycloaddition, is explored as a means to add biologically selective moieties to the particle surfaces, thus facilitating concentration at points of interest in the body. A variety of synthetic pathways are demonstrated, along with pre- and post-synthesis loading of the ionic species. Special attention is paid to amount surface density of functional groups from different synthetic conditions. Multifunctional capabilities of zeolites open a flood of possibilities for these particles, extending beyond MRI and PET, and into other medical applications, such as fluorescent imaging, drug delivery, and heat therapy. The materials were characterized by BET (Brunauer-Emmett-Teller) surface area measurements, FTIR (Fourier-transformed infrared) spectroscopy, TGA (thermogravimetric analysis), 1H NMR (nuclear magnetic resonance) spectroscopy, and ICP-OES (inductively coupled plasma optical emission spectrometry).