Poster Title (Current Submission)
Antioxidants, Heart Disease, and Nox4 in Between
Major(s)
Integrative Physiology
Mentor Name
Dr. Francis Miller
Other Mentor Department
Internal Medicine
Abstract
The formation of coronary artery disease (CAD) involves several cell types and processes. Smooth muscle cells play a distinct role in CAD formation, and an understanding of their physiology is necessary to successfully prevent the disease. Although antioxidants have proven unsuccessful in treating heart disease, oxidants produced by NADPH Oxidases (Noxs) remain important regulators of smooth muscle cell physiology. Here we show that Nox4 regulates the concentration of key antioxidants of the cell, and maintains cell survival against oxidative insults. These findings implicate Nox4 as sending out a survival signal maintaining cell viability, ultimately leading to disease.
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Antioxidants, Heart Disease, and Nox4 in Between
The formation of coronary artery disease (CAD) involves several cell types and processes. Smooth muscle cells play a distinct role in CAD formation, and an understanding of their physiology is necessary to successfully prevent the disease. Although antioxidants have proven unsuccessful in treating heart disease, oxidants produced by NADPH Oxidases (Noxs) remain important regulators of smooth muscle cell physiology. Here we show that Nox4 regulates the concentration of key antioxidants of the cell, and maintains cell survival against oxidative insults. These findings implicate Nox4 as sending out a survival signal maintaining cell viability, ultimately leading to disease.