Poster Title (Current Submission)

Antioxidants, Heart Disease, and Nox4 in Between

Major(s)

Integrative Physiology

Mentor Name

Dr. Francis Miller

Other Mentor Department

Internal Medicine

Presentation Date

March 2010

Abstract

The formation of coronary artery disease (CAD) involves several cell types and processes. Smooth muscle cells play a distinct role in CAD formation, and an understanding of their physiology is necessary to successfully prevent the disease. Although antioxidants have proven unsuccessful in treating heart disease, oxidants produced by NADPH Oxidases (Noxs) remain important regulators of smooth muscle cell physiology. Here we show that Nox4 regulates the concentration of key antioxidants of the cell, and maintains cell survival against oxidative insults. These findings implicate Nox4 as sending out a survival signal maintaining cell viability, ultimately leading to disease.

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Mar 27th, 12:00 AM

Antioxidants, Heart Disease, and Nox4 in Between

The formation of coronary artery disease (CAD) involves several cell types and processes. Smooth muscle cells play a distinct role in CAD formation, and an understanding of their physiology is necessary to successfully prevent the disease. Although antioxidants have proven unsuccessful in treating heart disease, oxidants produced by NADPH Oxidases (Noxs) remain important regulators of smooth muscle cell physiology. Here we show that Nox4 regulates the concentration of key antioxidants of the cell, and maintains cell survival against oxidative insults. These findings implicate Nox4 as sending out a survival signal maintaining cell viability, ultimately leading to disease.