Poster Title (Current Submission)

Optimization of Spray Dry Parameters for Anti-Biofilm Treatments

Major(s)

Chemical & Biochemical Engineering

Mentor Name

Jennifer Fiegel

Mentor Department

Chemical and Biochemical Engineering, Pharmacy

Presentation Date

3-27-2010

Abstract

Bacterial biofilms cause chronic lung infection because of their protective environment. Our focus is developing anti-biofilm aerosol treatments for inhalation. We have spray-dried aerosols of 0.4 wt% solutions containing antibiotic ciprofloxacin hydrochloride, dispersion compound glutamic acid, and flow property improvement excipient L-leucine via a factorial design of experiment (factors: pH and spray flow). We hope to optimize an aerosol formulation to obtain a mass median aerodynamic diameter less than 8 µm, geometric size distribution close to one for monodispersed particles, a high yield, a large fine particle fraction, and low powder hydration.

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Mar 27th, 12:00 AM

Optimization of Spray Dry Parameters for Anti-Biofilm Treatments

Bacterial biofilms cause chronic lung infection because of their protective environment. Our focus is developing anti-biofilm aerosol treatments for inhalation. We have spray-dried aerosols of 0.4 wt% solutions containing antibiotic ciprofloxacin hydrochloride, dispersion compound glutamic acid, and flow property improvement excipient L-leucine via a factorial design of experiment (factors: pH and spray flow). We hope to optimize an aerosol formulation to obtain a mass median aerodynamic diameter less than 8 µm, geometric size distribution close to one for monodispersed particles, a high yield, a large fine particle fraction, and low powder hydration.