Poster Title (Current Submission)

Optimization of Spray Dry Parameters for Anti-Biofilm Treatments

Major(s)

Chemical & Biochemical Engineering

Mentor Name

Dr. Jennifer Fiegel

Mentor Department

Chemical and Biochemical Engineering, Pharmacy

Abstract

Bacterial biofilms cause chronic lung infection because of their protective environment. Our focus is developing anti-biofilm aerosol treatments for inhalation. We have spray-dried aerosols of 0.4 wt% solutions containing antibiotic ciprofloxacin hydrochloride, dispersion compound glutamic acid, and flow property improvement excipient L-leucine via a factorial design of experiment (factors: pH and spray flow). We hope to optimize an aerosol formulation to obtain a mass median aerodynamic diameter less than 8 µm, geometric size distribution close to one for monodispersed particles, a high yield, a large fine particle fraction, and low powder hydration.

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Optimization of Spray Dry Parameters for Anti-Biofilm Treatments

Bacterial biofilms cause chronic lung infection because of their protective environment. Our focus is developing anti-biofilm aerosol treatments for inhalation. We have spray-dried aerosols of 0.4 wt% solutions containing antibiotic ciprofloxacin hydrochloride, dispersion compound glutamic acid, and flow property improvement excipient L-leucine via a factorial design of experiment (factors: pH and spray flow). We hope to optimize an aerosol formulation to obtain a mass median aerodynamic diameter less than 8 µm, geometric size distribution close to one for monodispersed particles, a high yield, a large fine particle fraction, and low powder hydration.