Poster Title (Current Submission)

Examining the Effects of VAP on Vinculin

Major(s)

Biochemistry

Minor(s)

Spanish

Mentor Name

Kris DeMali

Mentor Department

Biochemistry

Abstract

Extracellular matrix connections of integrins and actin-binding proteins such as vinculin are crucial elements of human health. Interruptions of these linkages contribute to the progression of numerous diseases including cancer, heart disease, and some muscular dystrophies. We have recently identified a short vinculin activating peptide (VAP), comprised of three vinculin binding sites (VBS) that increase integrin-mediated adhesion to fibronectin or collagen. Using a series of truncation mutants, we have mapped the residues sufficient for binding vinculin. We are investigating the mechanism by which the vinculin activating peptide increases adhesion and how these effects regulate integrin activity. These studies provide insight into how vinculin activation regulates integrin function and will open up new therapeutic possibilities.

Rights

Copyright © 2010 Melissa Palma

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Examining the Effects of VAP on Vinculin

Extracellular matrix connections of integrins and actin-binding proteins such as vinculin are crucial elements of human health. Interruptions of these linkages contribute to the progression of numerous diseases including cancer, heart disease, and some muscular dystrophies. We have recently identified a short vinculin activating peptide (VAP), comprised of three vinculin binding sites (VBS) that increase integrin-mediated adhesion to fibronectin or collagen. Using a series of truncation mutants, we have mapped the residues sufficient for binding vinculin. We are investigating the mechanism by which the vinculin activating peptide increases adhesion and how these effects regulate integrin activity. These studies provide insight into how vinculin activation regulates integrin function and will open up new therapeutic possibilities.