Poster Title (Current Submission)

Characterizing the Nephroblastoma Overexpressed gene (NOV) in Xenopus laevis.

Major

Neurobiology

Minor(s)

Chemistry

Mentor Name

Professor Doug Houston, Ph.D.

Mentor Department

Biology

Abstract

Cancer often involves molecular and cellular mechanisms also found during embryonic development. This research was conducted to determine the expression pattern and the functions in development of the Xenopus homologue of Nephroblastoma over-expressed (NOV), a human cancer-related gene. We analyzed the normal expression pattern of nov, which showed high levels of protein and mRNA expression in the outer ectoderm and notochord of the developing embryo. Interestingly, both over and under-expression of nov mRNA resulted in gastrulation and cell movement defects. Since gastrulation movements are controlled by non-canonical Wnt signaling, we are investigating the extent that Nov may inhibit these signals to control morphogenesis.

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Characterizing the Nephroblastoma Overexpressed gene (NOV) in Xenopus laevis.

Cancer often involves molecular and cellular mechanisms also found during embryonic development. This research was conducted to determine the expression pattern and the functions in development of the Xenopus homologue of Nephroblastoma over-expressed (NOV), a human cancer-related gene. We analyzed the normal expression pattern of nov, which showed high levels of protein and mRNA expression in the outer ectoderm and notochord of the developing embryo. Interestingly, both over and under-expression of nov mRNA resulted in gastrulation and cell movement defects. Since gastrulation movements are controlled by non-canonical Wnt signaling, we are investigating the extent that Nov may inhibit these signals to control morphogenesis.