Poster Title (Current Submission)

Neurofibromatosis II Protein – Merlin – Inhibiting Glial Tumorigenesis

Presenter Information

Nicolas A. AguilarFollow

Major(s)

Integrative Physiology

Minor(s)

Spanish

Mentor Name

Marlan Hansen

Other Mentor Department

Otolaryngology

Abstract

NF2 (Neurofibromatosis Type II) is a genetic disorder that gives rise to tumors in the brain and spine. These tumors are a result of an inactive tumor suppressor protein called Merlin. While Merlin's suppression of tumor growth has been well correlated in previous publications, its specific functioning in the body is still poorly understood.

The focus of my research is to shed light on the mechanism of the tumor suppressor Merlin by biologically engineering a fluorescent variant of Merlin. This new version of the protein can then be reintroduced into nerve tissue and Merlin’s cellular interactions can be directly monitored by fluorescent microscopy.

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Neurofibromatosis II Protein – Merlin – Inhibiting Glial Tumorigenesis

NF2 (Neurofibromatosis Type II) is a genetic disorder that gives rise to tumors in the brain and spine. These tumors are a result of an inactive tumor suppressor protein called Merlin. While Merlin's suppression of tumor growth has been well correlated in previous publications, its specific functioning in the body is still poorly understood.

The focus of my research is to shed light on the mechanism of the tumor suppressor Merlin by biologically engineering a fluorescent variant of Merlin. This new version of the protein can then be reintroduced into nerve tissue and Merlin’s cellular interactions can be directly monitored by fluorescent microscopy.