Poster Title (Current Submission)

Hydroxytyrosol suppresses aged-fibroblasts induced proliferation of human breast cancer cells

Mentor Name

Ehab H. Sarsour

Mentor Department

Free Radical and Radiation Biology

Abstract

The incidence of cancer increases with age. Although the mechanisms of age-associated increase in cancer are not completely understood, it is hypothesized that tumor microenvironment significantly influences epithelial malignancy. Fibroblasts are a major cell type in tumor microenvironment. Recent evidence suggests that fibroblasts could regulate proliferation of epithelial malignancy. Our results showed aged-fibroblasts facilitate proliferation of human breast cancer cells in an in vitro co-culture assay. Interestingly, aged-fibroblasts treated with hydroxytyrosol, a dietary antioxidant commonly found in olives, significantly suppressed proliferation of human breast cancer cells. These results suggest that dietary antioxidants promote healthy ageing of fibroblasts, and suppress proliferation of epithelial cancer cells.

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Hydroxytyrosol suppresses aged-fibroblasts induced proliferation of human breast cancer cells

The incidence of cancer increases with age. Although the mechanisms of age-associated increase in cancer are not completely understood, it is hypothesized that tumor microenvironment significantly influences epithelial malignancy. Fibroblasts are a major cell type in tumor microenvironment. Recent evidence suggests that fibroblasts could regulate proliferation of epithelial malignancy. Our results showed aged-fibroblasts facilitate proliferation of human breast cancer cells in an in vitro co-culture assay. Interestingly, aged-fibroblasts treated with hydroxytyrosol, a dietary antioxidant commonly found in olives, significantly suppressed proliferation of human breast cancer cells. These results suggest that dietary antioxidants promote healthy ageing of fibroblasts, and suppress proliferation of epithelial cancer cells.