Poster Title (Current Submission)

Hybrid Aerosols to Treat Bacterial Infections in the Lungs

Major(s)

Chemistry

Mentor Name

Jennifer Fiegel

Other Mentor Department

Pharmaceutics

Presentation Date

March 2011

Abstract

This project focuses on the development of spray dried aerosols for treatment of bacterial infections in the lungs. The aerosols contain the antibiotic ciprofloxacin hydrochloride, nutrient compound glutamic acid, and excipient leucine for better flow into the lungs. To optimize the aerosols, the design parameters of weight percent of solids in solution (0.025, 0.200, 0.375, 0.550, or 0.725%), pH (3, 5, 7, 9, or 11), inlet temperature (155, 165, 175, 185, or 195ºC), atomization air flow (150, 300, 450, 600, or 750 L/hr), and liquid flow rate (5, 7, 9, 11, or 13 mL/min) were investigated.

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Mar 26th, 12:00 AM

Hybrid Aerosols to Treat Bacterial Infections in the Lungs

This project focuses on the development of spray dried aerosols for treatment of bacterial infections in the lungs. The aerosols contain the antibiotic ciprofloxacin hydrochloride, nutrient compound glutamic acid, and excipient leucine for better flow into the lungs. To optimize the aerosols, the design parameters of weight percent of solids in solution (0.025, 0.200, 0.375, 0.550, or 0.725%), pH (3, 5, 7, 9, or 11), inlet temperature (155, 165, 175, 185, or 195ºC), atomization air flow (150, 300, 450, 600, or 750 L/hr), and liquid flow rate (5, 7, 9, 11, or 13 mL/min) were investigated.