Poster Title (Current Submission)
Hybrid Aerosols to Treat Bacterial Infections in the Lungs
Major(s)
Chemistry
Mentor Name
Jennifer Fiegel
Other Mentor Department
Pharmaceutics
Abstract
This project focuses on the development of spray dried aerosols for treatment of bacterial infections in the lungs. The aerosols contain the antibiotic ciprofloxacin hydrochloride, nutrient compound glutamic acid, and excipient leucine for better flow into the lungs. To optimize the aerosols, the design parameters of weight percent of solids in solution (0.025, 0.200, 0.375, 0.550, or 0.725%), pH (3, 5, 7, 9, or 11), inlet temperature (155, 165, 175, 185, or 195ºC), atomization air flow (150, 300, 450, 600, or 750 L/hr), and liquid flow rate (5, 7, 9, 11, or 13 mL/min) were investigated.
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Hybrid Aerosols to Treat Bacterial Infections in the Lungs
This project focuses on the development of spray dried aerosols for treatment of bacterial infections in the lungs. The aerosols contain the antibiotic ciprofloxacin hydrochloride, nutrient compound glutamic acid, and excipient leucine for better flow into the lungs. To optimize the aerosols, the design parameters of weight percent of solids in solution (0.025, 0.200, 0.375, 0.550, or 0.725%), pH (3, 5, 7, 9, or 11), inlet temperature (155, 165, 175, 185, or 195ºC), atomization air flow (150, 300, 450, 600, or 750 L/hr), and liquid flow rate (5, 7, 9, 11, or 13 mL/min) were investigated.