Document Type

Article

Peer Reviewed

1

Publication Date

7-25-2016

Journal/Book/Conference Title

Breast Cancer – Targets and Therapy

DOI of Published Version

10.2147/BCTT.S110765

Abstract

Breast cancer in the elderly is an increasing clinical problem. In addition, ~60% of deaths from breast cancer occur in women aged 65 years and older. Despite this, older women with breast cancer have been underrepresented in clinical trials, and this has led to less than optimal evidence to guide their therapy. The management of elderly women with early breast cancer is a complex process that requires careful evaluation of life expectancy, comorbidities, patient values, and risks and benefits of available treatment options. This review will focus on current adjuvant systemic therapy options for older women with breast cancer, discuss the principles in the decision-making process, and define the role of endocrine therapy, chemotherapy, and targeted agents.

Keywords

OAfund, breast cancer, adjuvant therapy, chemotherapy, endocrine therapy, elderly

Journal Article Version

Version of Record

Published Article/Book Citation

Breast Cancer – Targets and Therapy. 25 July 2016 Volume 2016:8 Pages 141—147. DOI 10.2147/BCTT.S110765

Rights

© 2016 Leone et al.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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URL

http://ir.uiowa.edu/internalmedicine_pubs/14