Document Type

Article

Peer Reviewed

1

Publication Date

1-1-2016

NLM Title Abbreviation

World Allergy Organ J

Journal/Book/Conference Title

World Allergy Organization Journal

PubMed ID

27458500

DOI of Published Version

10.1186/s40413-016-0113-4

Total Pages

3

Abstract

BACKGROUND: Eosinophilic cystitis is a rare inflammatory disorder characterized by eosinophilic infiltration of all layers of the urinary bladder wall. Due to lack of consensus and potential for side effect from various therapeutic options, treatment of the disease is often challenging.

CASE PRESENTATION: A 64-year old woman with hypertensive nephropathy resulting in stage III chronic kidney disease, obstructive sleep apnea, and obstructive lung disease presented with a 4 month history of dysuria, urgency, frequency, and persistent hematuria. Based on eosinophilic infiltration on bladder wall biopsy in the absence of any evidence of infection, malignancy, or immune disorder, she was diagnosed with eosinophilic cystitis. Despite multiple medication regimens, her symptoms persisted, requiring high-dose prednisone with steroid-related side effects. After four months, she was started on cyclosporine, which led to symptomatic improvement and reduction in prednisone dosage. At that time, repeat urine cytology and cystoscopy did not reveal friable tissues or eosinophiluria.

CONCLUSION: This case illustrates the utility of using cyclosporine to treat eosinophilic cystitis in adult patient with multiple comorbid conditions.

Keywords

OAfund, Eosinophilic cystitis, Cyclosporine, Steroids

Journal Article Version

Version of Record

Published Article/Book Citation

World Allergy Organization Journal, 2016 9:22. DOI: 10.1186/s40413-016-0113-4

Rights

© Aleem et al. 2016

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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URL

http://ir.uiowa.edu/internalmedicine_pubs/18