Document Type

Article

Peer Reviewed

1

Publication Date

9-13-2016

NLM Title Abbreviation

Int J Mol Sci

Journal/Book/Conference Title

International journal of molecular sciences

PubMed ID

27649142

DOI of Published Version

10.3390/ijms17091543

Abstract

The discovery of various driver pathways and targeted small molecule agents/antibodies have revolutionized the management of metastatic breast cancer. Currently, the major targets of clinical utility in breast cancer include the human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) receptor, mechanistic target of rapamycin (mTOR) pathway, and the cyclin-dependent kinase 4/6 (CDK-4/6) pathway. Brain metastasis, however, remains a thorn in the flesh, leading to morbidity, neuro-cognitive decline, and interruptions in the management of systemic disease. Approximately 20%-30% of patients with metastatic breast cancer develop brain metastases. Surgery, whole brain radiation therapy, and stereotactic radiosurgery are the traditional treatment options for patients with brain metastases. The therapeutic paradigm is changing due to better understanding of the blood brain barrier and the advent of tyrosine kinase inhibitors and monoclonal antibodies. Several of these agents are in clinical practice and several others are in early stage clinical trials. In this article, we will review the common targetable pathways in the management of breast cancer patients with brain metastases, and the current state of the clinical development of drugs against these pathways.

Keywords

oafund, Antibodies, Monoclonal, Antineoplastic Agents, Blood-Brain Barrier, Brain Neoplasms, Breast Neoplasms, Clinical Trials as Topic, Female, Humans, Molecular Targeted Therapy, Protein Kinase Inhibitors, Signal Transduction, Survival Analysis, Treatment Outcome

Journal Article Version

Version of Record

Published Article/Book Citation

Venur, V.A.; Leone, J.P. Targeted Therapies for Brain Metastases from Breast Cancer. Int. J. Mol. Sci. 2016, 17, 1543. http://doi.org/10.3390/ijms17091543

Rights

© 2016 by the authors

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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URL

http://ir.uiowa.edu/internalmedicine_pubs/20