Document Type

Article

Peer Reviewed

1

Publication Date

3-9-2015

NLM Title Abbreviation

Cancer Med

Journal/Book/Conference Title

Cancer Medicine

PubMed ID

25756607

DOI of Published Version

10.1002/cam4.439

Total Pages

6

Abstract

Brain metastasis (BM) in patients with breast cancer is a catastrophic event that results in poor prognosis. Identification of prognostic factors associated with breast cancer brain metastases (BCBM) could help to identify patients at risk. The aim of this study was to assess clinical characteristics, prognostic factors, and survival of patients with BCBM who had craniotomy and resection in a series of patients treated with modern multimodality therapy. We analyzed 42 patients with BCBM who underwent resection. Patients were diagnosed with breast cancer between April 1994 and May 2010. Cox proportional hazards regression was selected to describe factors associated with time to BM, survival from the date of first recurrence, and overall survival (OS). Median age was 51 years (range 24-74). Median follow-up was 4.2 years (range 0.6-18.5). The proportion of the biological subtypes of breast cancer was ER+/HER2- 25%, ER+/HER2+ 15%, ER-/HER2+ 30%, and ER-/HER2- 30%. Median OS from the date of primary diagnosis was 5.74 years. Median survival after diagnosis of BM was 1.33 years. In multivariate Cox regression analyses, stage was the only factor associated with shorter time to the development of BM (P = 0.033), whereas age was the only factor associated with survival from the date of recurrence (P = 0.027) and with OS (P = 0.037). Stage at primary diagnosis correlated with shorter time to the development of BM, while age at diagnosis was associated with shorter survival in BCBM. None of the other clinical factors had influence on survival.

Keywords

OAfund, Brain metastasis, breast cancer, craniotomy, pronostic factors, survival

Journal Article Version

Version of Record

Published Article/Book Citation

Cancer Medicine, Early View (Online version of Record published before inclusion in an issue). DOI: 10.1002/cam4.439

Rights

Copyright © 2015, Jose Pablo Leone, Adrian V. Lee, and Adam M. Brufsky. Posted by permission.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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URL

http://ir.uiowa.edu/internalmedicine_pubs/7