Document Type

Article

Peer Reviewed

1

Publication Date

9-1-2017

Journal/Book/Conference Title

eNeurologicalSci

DOI of Published Version

10.1016/j.ensci.2017.08.004

Total Pages

2

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare diseases characterized by a necrotizing small-vessel vasculitis and circulating ANCA that comprise granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (EGPA). Acute ischemic stroke (AIS) can be a manifestation of central nervous system (CNS) involvement in these diseases. Furthermore, intracerebral hemorrhage (ICH) is a potential complication of these necrotizing vasculitides. We describe a case of AAV who presented with acute ischemic stroke and developed multiple ICHs after administration of IV tPA. We propose that patients with AAV are more prone to develop hemorrhage in the presence of IV tPA and discuss the possible underlying pathogenesis. We suggest that AAV should be considered a contraindication for administration of IV tPA.

Keywords

OAfund, ANCA associated vasculitis, Intracerebral hemorrhage, Ischemic stroke, IV tPA

Journal Article Version

Version of Record

Published Article/Book Citation

eNeurologicalSci 9 (2017)

https://doi.org/10.1016/j.ensci.2017.08.004

Rights

Copyright (c) 2017 The Authors

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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URL

http://ir.uiowa.edu/neurology_pubs/3