Title

The anticholinergic drug scale as a measure of drug-related anticholinergic burden: Associations with serum anticholinergic activity

Document Type

Article

Peer Reviewed

1

Publication Date

1-1-2006

Journal, Book or Conference Title

Journal of clinical pharmacology

NLM Title Abbreviation

J Clin Pharmacol

PubMed ID

12858139

DOI

10.1177/0091270006292126

Abstract

Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long-term care facility residents who were not included in the pilot study. Simple and multiple linear regression models were then used to determine whether the ADS could be modified to more effectively predict SAA in all 297 subjects. In the replication analysis, ADS scores were significantly associated with SAA (R-2 =.0947, P <.0001). In the modification analysis, each model significantly predicted SAA, including ADS scores (R-2 =.0741, P <.0001). The modifications examined did not appear useful in optimizing the ADS. This study replicated findings on the association of the ADS with SAA. Future work will determine whether the ADS is clinically useful for preventing anticholinergic adverse effects.

Published Article/Book Citation

The definitive version was published in Journal of clinical pharmacology, 46:12 (2006) pp.1481-1486. DOI:10.1177/0091270006292126.

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URL

http://ir.uiowa.edu/nursing_pubs/196