Title

Communication, encouragement, and cancer screening in families with and without mutations for hereditary nonpolyposis colorectal cancer: a pilot study

Document Type

Article

Peer Reviewed

1

Publication Date

10-1-2009

Journal, Book or Conference Title

Genetics in medicine

NLM Title Abbreviation

Genet Med

PubMed ID

19707152

DOI

10.1097/GIM.0b013e3181b3f42d

Abstract

PURPOSE: Known and suspected mutation carriers for hereditary nonpolyposis colorectal cancer are advised to have colonoscopies every 1 to 2 years to detect colorectal cancer. Little is known about colonoscopy completion in families suspected of having hereditary nonpolyposis colorectal cancer but without identified mutations. METHODS: This study examined the effect of communication and encouragement on colonoscopy in families with and without known mutations. Twenty-three respondents from 11 families with indeterminate genetic test results were matched with 23 respondents from 11 families with mutation-positive results. Hierarchical modeling examined the effects of relational characteristics on time since last colonoscopy in index cases and their first-degree relatives. RESULTS: Nearly one fifth of respondents were not screening appropriately. Time since last screening did not differ according to family mutation status. However, respondents who communicated about risk and received encouragement to screen from a greater proportion of named family members, and those who had a greater proportion of named family members involved in both communication and encouragement were significantly more likely to have a shorter time interval since last colonoscopy. CONCLUSION: Identifying patterns of interaction within at-risk families, regardless of gene mutation status, may be one avenue for promoting screening adherence.

Keywords

Adult, Case-Control Studies, Colonoscopy/statistics & numerical data/utilization, Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis/genetics/psychology, Communication, Counseling/statistics & numerical data, Early Detection of Cancer/psychology/statistics & numerical data, Family, Female, Genetic Predisposition to Disease, Health Promotion/methods/statistics & numerical data, Humans, Male, Middle Aged, Mutation/physiology, Pilot Projects

Published Article/Book Citation

The definitive version was published in Genetics in medicine, 11:10 (2009) pp.728-734. DOI:10.1097/GIM.0b013e3181b3f42d.

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URL

http://ir.uiowa.edu/nursing_pubs/691