Document Type


Peer Reviewed


Publication Date


NLM Title Abbreviation

J Soc Pediatr Nurs

Journal/Book/Conference Title

Journal of the Society of Pediatric Nurses

PubMed ID


DOI of Published Version



PURPOSE: To determine the effects of saline, heparin 2 units (U) per ml saline, and heparin 10 U/ml saline flush solutions on the duration of intravenous (i.v.) locks and the incidence of i.v. infiltration in neonates. DESIGN: Randomized double-blind experiment. SETTING: Tertiary-care nursery. PARTICIPANTS: Neonates (N = 90) hospitalized at birth in the intensive, intermediate care, or newborn units. MAIN OUTCOME MEASURES: Total hours from the time the i.v. was inserted to the time the i.v. was removed; hours from the time the i.v. was first flushed to the time the i.v. was removed; number of i.vs. removed because of infiltration. RESULTS: No statistical or clinical differences between the three groups for duration of i.v. nor for incidence of complications. CONCLUSIONS: The use of heparin in i.v. lock flush solution did not affect the duration of i.v. locks nor the incidence of infiltration in neonates.


Anticoagulants/therapeutic use, Catheterization, Peripheral/methods, Double-Blind Method, Female, Heparin/therapeutic use, Humans, Infant, Newborn, Infusions, Intravenous/methods, Male, Neonatal Nursing, Sodium Chloride/therapeutic use

Published Article/Book Citation

The definitive version was published in Journal of the Society of Pediatric Nurses, 3:3 (1998) pp.111-116.


Author posting. Copyright © Wiley, 1998. This article is posted here by permission of John Wiley and Sons, Inc. for personal use, not for redistribution.