Title

Strategies for salivary cortisol collection and analysis in research with children

Document Type

Article

Peer Reviewed

1

Publication Date

5-1-2006

Journal, Book or Conference Title

Applied Nursing Research

NLM Title Abbreviation

Appl Nurs Res

PubMed ID

16728293

DOI

10.1016/j.apnr.2006.02.001

Abstract

Salivary cortisol has emerged in pediatric research as an easy-to-collect, relatively inexpensive, biologic marker of stress. Cortisol is highly variable and is responsive to a wide range of factors that should be considered when incorporating this measure into research with children. Strategies for sample collection include: (1) standardizing the time for sample collection, including baseline samples; (2) using consistent collection materials and methods; (3) controlling for certain drinks, foods, medications, and diagnoses; and (4) establishing procedures and protocols. Other strategies for laboratory analyses include: (1) selecting the appropriate assay and laboratory; (2) identifying units of measure and norms; and (3) establishing quality controls. These strategies control extraneous variables and produce reliable and valid salivary cortisol results.

Keywords

Bias (Epidemiology), Child, Clinical Nursing Research/methods/standards, Clinical Protocols, Data Collection/methods, Data Interpretation, Statistical, Humans, Hydrocortisone/analysis/secretion, Parents/education, Patient Education as Topic, Patient Selection, Pediatric Nursing, Questionnaires, Reference Values, Reproducibility of Results, Saliva/chemistry/drug effects, Sensitivity and Specificity, Specimen Handling/methods/nursing/standards, Stress, Physiological/diagnosis/metabolism, Time Factors

Published Article/Book Citation

The definitive version was published in Applied Nursing Research, 19:2 (2006) pp.95-101. DOI:10.1016/j.apnr.2006.02.001.

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URL

http://ir.uiowa.edu/nursing_pubs/837