Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.
Adaptor Proteins, Signal Transducing, Animals, B-Lymphocytes, Gene Targeting, Immunoglobulin M, Killer Cells, Natural, Leukopoiesis, Lymph Nodes, Lymphocyte Activation, Lymphocyte Count, Macrophages, Mice, Mice, Inbred C57BL, Phosphoproteins, Protein-Tyrosine Kinases, Receptors, Antigen, T-Cell, Signal Transduction, Spleen, T-Lymphocytes, Thymus Gland, ZAP-70 Protein-Tyrosine Kinase
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