Title

Progesterone: the ultimate endometrial tumor suppressor

Document Type

Article

Peer Reviewed

1

Publication Date

4-1-2011

Volume

22

Journal, Book or Conference Title

Trends in endocrinology and metabolism: TEM

PubMed ID

21353793

DOI

10.1016/j.tem.2011.01.005;

Abstract

The uterine endometrium is exquisitely sensitive to steroid hormones that act through well-described nuclear receptors. Estrogen drives epithelial proliferation, and progesterone inhibits growth and causes cell differentiation. The importance of progesterone as a key inhibitor of carcinogenesis is reflected by the observation that women who ovulate and produce progesterone almost never get endometrial cancer. In this review we describe seminal research findings that define progesterone as the major endometrial tumor suppressor. We discuss the genes and diverse signaling pathways that are controlled by progesterone through progesterone receptors (PRs) and also the multiple factors that regulate progesterone/PR activity. By defining these progesterone-regulated factors and pathways we identify the principal therapeutic opportunities to control the growth of endometrial cancer.

Keywords

Endometrial Neoplasms/drug therapy/metabolism, Female, Humans, Progesterone/metabolism, Progestins/therapeutic use, Receptors, Progesterone/metabolism

NLM Title Abbreviation

Trends Endocrinol Metab



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URL

http://ir.uiowa.edu/obgyn_pubs/41