Title

Inhibition of interleukin-10 during pregnancy results in neonatal growth retardation

Document Type

Article

Peer Reviewed

1

Publication Date

3-1-1997

NLM Title Abbreviation

Am J Reprod Immunol

Journal/Book/Conference Title

American journal of reproductive immunology (New York, N.Y.: 1989)

PubMed ID

9127644

Abstract

PROBLEM: Interleukin 10 is considered to be important in the survival of the fetus in murine pregnancies that are known to be at risk for fetal wastage. The function of IL-10 in a normal pregnancy is not known. METHODS: In this report, we attempted to neutralize Interleukin 10 by administering anti IL-10 monoclonal antibodies (mAb) to pregnant mice that have a low background risk for fetal resorptions. The first group of mice was sacrificed on gestation day 18 to study the fetal effects of anti IL-10 administration. The second group of mice was allowed to deliver to study the effects on the neonatal outcome. RESULTS: Administration of anti IL-10 mAb did not affect the duration of gestation or the fetal outcome. Neonates exposed to anti IL-10 mAb in utero showed signs of transient growth deficiency starting at 4 weeks of age that spontaneously corrected by 6 weeks of age. CONCLUSIONS: Administration of anti IL-10 mAb does not alter the duration of gestation or the fetal outcome in normal murine pregnancies; however, it appears to be associated with transient neonatal growth problems.

Keywords

Animals, Animals, Newborn, Antibodies, Monoclonal/pharmacology, Birth Weight/drug effects, Cell Differentiation/immunology, Female, Fetal Growth Retardation/etiology/immunology, Interleukin-10/antagonists & inhibitors/immunology, Male, Mice, Mice, Inbred BALB C, Pregnancy, Pregnancy Outcome, T-Lymphocytes/cytology/immunology, Thymus Gland/immunology

Published Article/Book Citation

American journal of reproductive immunology (New York, N.Y.: 1989), 37:3 (1997) pp.232-235.

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URL

http://ir.uiowa.edu/obgyn_pubs/891