Inhibition of interleukin-10 during pregnancy results in neonatal growth retardation
NLM Title Abbreviation
Am J Reprod Immunol
American journal of reproductive immunology (New York, N.Y.: 1989)
PROBLEM: Interleukin 10 is considered to be important in the survival of the fetus in murine pregnancies that are known to be at risk for fetal wastage. The function of IL-10 in a normal pregnancy is not known. METHODS: In this report, we attempted to neutralize Interleukin 10 by administering anti IL-10 monoclonal antibodies (mAb) to pregnant mice that have a low background risk for fetal resorptions. The first group of mice was sacrificed on gestation day 18 to study the fetal effects of anti IL-10 administration. The second group of mice was allowed to deliver to study the effects on the neonatal outcome. RESULTS: Administration of anti IL-10 mAb did not affect the duration of gestation or the fetal outcome. Neonates exposed to anti IL-10 mAb in utero showed signs of transient growth deficiency starting at 4 weeks of age that spontaneously corrected by 6 weeks of age. CONCLUSIONS: Administration of anti IL-10 mAb does not alter the duration of gestation or the fetal outcome in normal murine pregnancies; however, it appears to be associated with transient neonatal growth problems.
Animals, Animals, Newborn, Antibodies, Monoclonal/pharmacology, Birth Weight/drug effects, Cell Differentiation/immunology, Female, Fetal Growth Retardation/etiology/immunology, Interleukin-10/antagonists & inhibitors/immunology, Male, Mice, Mice, Inbred BALB C, Pregnancy, Pregnancy Outcome, T-Lymphocytes/cytology/immunology, Thymus Gland/immunology
Published Article/Book Citation
American journal of reproductive immunology (New York, N.Y.: 1989), 37:3 (1997) pp.232-235.