Ampicillin/sulbactam versus ampicillin alone for cesarean section prophylaxis: a randomized double-blind trial

Document Type


Peer Reviewed


Publication Date


NLM Title Abbreviation

Am J Perinatol

Journal/Book/Conference Title

American Journal of Perinatology

PubMed ID


DOI of Published Version



To study the effectiveness of anaerobic coverage in prevention of postpartum endometritis in women undergoing nonelective cesarean sections, we conducted a randomized prospective double-blind study of women undergoing cesarean sections and requiring antibiotic prophylaxis from April 1, 1989, through December 31, 1990. Ninety-four patients were enrolled in the study. Forty-five patients received ampicillin alone and 46 received ampicillin in conjunction with sulbactam. All patients were evaluated prior to surgery and in the postoperative period. Ninety-one patients completed the study and their records were analyzed. Patients were divided into two groups depending on the presence or absence of ruptured membranes. Seventy-five percent of patients had ruptured membranes. Failure of prophylaxis and subsequent endometritis was documented in 8.8% of patients who received ampicillin and sulbactam and 35.3% of patients who received ampicillin alone. This difference was statistically significant (p < 0.02). In conclusion, single-dose ampicillin and sulbactam provides better prophylaxis than single-dose ampicillin in women undergoing cesarean section with rupture of membranes.


Adult, Ampicillin/therapeutic use, Antibiotic Prophylaxis, Cesarean Section, Double-Blind Method, Drug Therapy, Combination/therapeutic use, Female, Humans, Pregnancy, Prospective Studies, Sulbactam/therapeutic use

Published Article/Book Citation

American Journal of Perinatology, 12:5 (1995) pp.322-324.

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