Inventor

Vasu Nair

Document Type

Patent

Patent Number

US Patent 5,231,174

Patent agency

United States Patent and Trademark Office

Publication Date

7-27-1993

Assignee

University of Iowa Research Foundation (Oakdale, IA, US)

Application Number

07/843,913

Date Filed

1992-02-27

Total Pages

8 pages

Abstract

The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'β-D-nucleosides and their derivatives where the base moiety has β-stereochemistry but is transposed from the normal 1'-position to the 2'-position and the carbohydrate moiety has the D-configuration at the 4'-position. These compounds are resistant towards hydrolytic cleavage of the glycosidic bond and are resistant to enzymatic deamination. They have potential in the treatment or prophylaxis of viral infections, particularly retroviral infections and especially AIDS.

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URL

https://ir.uiowa.edu/patents/107