Document Type

Patent

Patent Number

US Patent 5,962,429

Patent agency

United States Patent and Trademark Office

Publication Date

10-5-1999

Assignee

University of Iowa (Iowa City, IA, US)

Application Number

08/755,035

Date Filed

1996-11-22

Total Pages

32 pages

Abstract

The present invention provides noncovalent complexes of cationic molecules and adenoviral vectors containing a transgene. The complexes of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the complexes are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to a CF patient utilizing a complex of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.

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URL

https://ir.uiowa.edu/patents/225