Document Type

Patent

Patent Number

US Patent 6,159,735

Patent agency

United States Patent and Trademark Office

Publication Date

12-12-2000

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

08/457,996

Date Filed

1995-06-01

Total Pages

33 pages

Abstract

A DNA element which was isolated from the upstream regulatory region of the CT/CGRP gene and which exhibits cell-specific enhancement of transcription is described. The enhancer activity of the element is further regulated by members of the superfamily of steroids and retinoids which increase or decrease transcription in a cell-specific manner. Methods of gene regulation and therapeutic uses involving the DNA element are also described. Furthermore, proteins which bind to the element and regulate transcription of genes under the control of the DNA element are also described. These proteins can be used for purposes of regulation of gene expression.

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URL

https://ir.uiowa.edu/patents/251