Inventor

Richard J. Smith

Document Type

Patent

Patent Number

US Patent 7,741,469

Patent agency

United States Patent and Trademark Office

Publication Date

6-22-2010

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

11/732,619

Date Filed

2007-04-04

Total Pages

45 pages

Abstract

This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of genes encoding proteins involved in deafness caused by dominant negative mechanism of action by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes involved in deafness caused by dominant negative mechanism of action.

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URL

https://ir.uiowa.edu/patents/513