Endometrial cancer is the most common gynecological cancer and the fourth most common cancer in women worldwide. In spite of its’ relative importance to overall morbidity among women, molecular research in endometrial cancers lags far behind other cancers such as breast and colorectal. Nowhere is this more true than in research in the newly emergent field of post-transcriptional gene regulation by small, regulatory RNAs, primarily microRNAs (miRNAs). Here, structure, biogenesis, and mode of action of miRNAs is presented along with a brief overview of the role of miRNAs in carcinogenesis and a review of the few miRNA studies in endometrial cancer carried out to date.
microRNA, cancer, cellular behavior, dysregulation, endometrial cancer
The authors report no conflict of interest.
Copyright © The University of Iowa, 2010.
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