There is conflicting evidence on the association between PCOS and early and late obstetric complications. It is unclear if the reported risks are independent of BMI, preexisting hypertension and diabetes. We performed a retrospective chart review to examine the risk of early and late obstetrical complications after IVF in women with PCOS (n=130) compared to controls (n=130). The miscarriage rate was 17.7% in PCOS women and 15.4% in controls. PCOS was not associated with miscarriage independent of age and BMI. The prevalence of gestational DM (GDM) was similar in both groups (12% PCOS versus 11% controls). BMI was independently associated with GDM (p=0.01). Risk of both preeclampsia and PIH was 10% in PCOS and 5% in controls, but not statistically significant. Preexisting HTN showed a significant association with preeclampsia (p<0.01). There was no significant difference in preterm delivery, twin gestation, intrauterine fetal death and intrauterine growth restriction in the 2 groups. Our study did not detect an increased risk of miscarriage in women with PCOS undergoing IVF. Obesity was a significant contributor to late obstetric complications, namely GDM. These findings warrant counseling of women with PCOS especially prior to IVF on the potential benefits of weight loss prior to pregnancy.
PCOS, pregnancy, gestational diabetes, obesity, miscarriage
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