Volume 2, Issue 1 (July 2011) Gynecologic Oncology

Review Articles


Hormones and receptors in endometrial cancer Article 1
David Bender, Thomas Buekers, and Kimberly Leslie



Toward a microRNA signature of endometrial cancer Article 2
Eric J. Devor, Michael J. Goodheart, and Kimberly K. Leslie

Case Reports


Positron emission tomography in detection of metastatic leiomyosarcoma in a postoperative patient: a case report Article 14
David B. Engle, Linda M. Smiley, Scott L. Baum, and Greg P. Wellman

Board Member Spotlight


Michael J. Goodheart, MD Article 3
Kristina W. Thiel



The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer Article 4
Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, Donghai Dai, Thomas E. Buekers, David P. Bender, and Kimberly K. Leslie


Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells Article 5
Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, and Kimberly K. Leslie


H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium. Article 7
Eric J. Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, and Kimberly K. Leslie


MiR-888: A newly identified miRNA significantly over-expressed in endometrial cancers Article 8
Adriann M. Hovey, Eric J. Devor, and Kimberly K. Leslie


Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors Article 9
Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, and Michael Goodheart


Comparison of P53 mutation status, primary cytoreductive surgical outcomes, and overall survival in patients with ovarian cancer Article 10
David Engle, Hubert Fornalik, Traci Neff, Anna Button, K Collins, Amina Ahmed, David Bender, Susan Lutgendorf, and Michael Goodheart


The relationship between vascularity, p53 gene mutations and distant metastatic disease in epithelial ovarian carcinoma Article 11
Janna Girardi, Megan Samuelson, Anna Button, Koen De Geest, David P. Bender, Amina Ahmed, and Michael Goodheart


Zmiz1 is overexpressed in epithelial ovarian cancer and associated with p53 gene mutations Article 12
Niyati J. Nadkarni, Laura M. Rogers, Megan Samuelson, Traci Neff, David P. Bender, Amina Ahmed, Koen De Geest, Anna Button, Adam Dupuy, and Michael Goodheart

Extended Abstracts


Long-term Outcomes Among Women With Cervical Cancer Treated from 1960-1987 Article 13
Christopher Yopp, Jo Benda, Colleen Stockdale, Jami L. Shepard, and Amina Ahmed


Kimberly K. Leslie, MD, The University of Iowa

Guest Editor

Michael J. Goodheart, MD Gynecologic Oncology, The University of Iowa

Managing Editor

Susan Schwartz-Rogers, MLS, The University of Iowa

Scientific Associate Editor

Kristina W. Thiel, PhD, The University of Iowa

Welcome to the first issue of the second volume of Proceedings in Obstetrics and Gynecology. I am please to serve as the guest editor of this issue, which is focused on topics related to gynecologic oncology. I have been a faculty member in the Division of Gynecologic Oncology in the Department of Obstetrics and Gynecology at the University of Iowa since 2005.

Included in this themed issue is a wide range of articles relevant to gynecologic oncology. From case studies of diagnostic approaches to treatment and care to articles on pathways and biomarkers involved in gynecologic cancers, this issue provides a nice cross section of the current state of the gynecologic oncology field. I am pleased to have contributed to this exciting issue of Proceedings in Obstetrics and Gynecology.

Our journal is peer-reviewed, and we invite your interest and future submissions. Our eventual goal is to become listed in PubMed, so your support in submitting the most interesting clinical studies, reviews and basic research manuscripts is particularly valuable as we move forward. In addition to full length articles, we will publish case reports and interesting clinical cases for review by one of our faculty experts. Please see our instructions for authors and instructions for clinical cases/case reports templates.

On behalf of the Editorial Board including Susan Schwartz-Rogers, the Managing Editor, welcome to Proceeding in Obstetrics and Gynecology! We hope you enjoy our current issue.


Michael J. Goodheart, M.D. Division of Gynecologic Oncology Department of Obstetrics and Gynecology The University of Iowa