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Abstract

Mutations of the p53 tumor suppressor gene are associated with large differences (>7 vessels/HPF) in Microvessel density (MVD) counts between primary and metastatic tumor sites in patients with epithelial ovarian cancer. These data are consistent with models demonstrating p53 mutation functions directly to influence angiogenesis. This information supports continued therapy and research involving angiogenesis inhibitors in patients with ovarian cancer, especially in the setting of increased differences in MVD between primary and metastatic sites.

Keywords

vascularity, P53, gene mutations, metastatic disease, epithelial, ovarian cancer

Submission Type

Article

Rights

Copyright © Janna Girardi, Megan Samuelson, Anna Button, Koen De Geest, David P. Bender, Amina Ahmed, Michael J. Goodheart, 2011.

Creative Commons License


This work is licensed under a Creative Commons Attribution 3.0 License.