Proceedings in Obstetrics and Gynecology

Authors

Xiangbing Meng, University of IowaFollow
Laura L. Laidler, University of New Mexico
Lina Albitar, University of New Mexico
Anna M. Holmes, University of New Mexico
Donghai Dai, University of New Mexico
Thomas E. Buekers, University of Iowa
David P. Bender, University of Iowa
Kimberly K. Leslie, University of Iowa

Article Title

The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer

Abstract

Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.

Keywords

Paclitaxel, Gefitinib, endometrial cancer, mitotic catastrophe, p38, p53

Submission Type

Article

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Recommended Citation

Meng X, Laidler LL, Albitar L, Holmes AM, Dai D, Buekers TE, Bender DP, Leslie KK. The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 4 [2 p.]. Available from: http://ir.uiowa.edu/pog/vol2/iss1/4. Free full text article.