Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.


MTDH, Metadherin, TRAIL, LBH 589, HDAC

Total Pages



Copyright © Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, and Kimberly K. Leslie, 2011.

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.