Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.
MTDH, Metadherin, TRAIL, LBH 589, HDAC
Copyright © Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, and Kimberly K. Leslie, 2011.
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Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Leslie KK. Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 5 [2 p.]. https://doi.org/10.17077/2154-4751.1100. Free full text article.