H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.
endometrium, endometrial cancer, RNA
This work supported in part by NIH 2CA99908-7 and the Department of Obstetrics and Gynecology Research and Development Fund.
Copyright © Eric J. Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, and Kimberly K. Leslie, 2011.
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Devor EJ, DeMik JN, Schickling BM, Goodheart MJ, Leslie KK. H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 7 [1 p.]. https://doi.org/10.17077/2154-4751.1101. Free full text article.