Proceedings in Obstetrics and Gynecology

Authors

Eric J. Devor, University of IowaFollow
Jill N. DeMik, University of Iowa
Brandon M. Schickling, University of Iowa
Michael J. Goodheart, University of Iowa
Kimberly K. Leslie, University of Iowa

Article Title

H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

Abstract

H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.

Keywords

endometrium, endometrial cancer, RNA

Financial Disclosure

This work supported in part by NIH 2CA99908-7 and the Department of Obstetrics and Gynecology Research and Development Fund.

Submission Type

Article

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Recommended Citation

Devor EJ, DeMik JN, Schickling BM, Goodheart MJ, Leslie KK. H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 7 [1 p.]. Available from: http://ir.uiowa.edu/pog/vol2/iss1/7. Free full text article.