Proceedings in Obstetrics and Gynecology

Authors

Aine Clements, University of Iowa
David Engle, University of Iowa
Dawne Shelton, University of Iowa
Traci Neff, University of Iowa
Soo Park, University of Iowa
David Bender, University of Iowa
Amina Ahmed, University of Iowa
Koen De Geest, University of Iowa
Anna Button, University of Iowa
John F. Engelhardt, University of Iowa
Michael GoodheartFollow

Article Title

Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors

Abstract

Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.

Keywords

LEF-1, ovarian cancer, fallopian tube cancer, peritoneal cancer

Submission Type

Article

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Recommended Citation

Clements A, Engle D, Shelton D, Neff T, Park S, Bender D, Ahmed A, De Geest K, Button A, Engelhardt JF, Goodheart M. Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 9 [2 p.]. Available from: http://ir.uiowa.edu/pog/vol2/iss1/9. Free full text article.