Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.
LEF-1, ovarian cancer, fallopian tube cancer, peritoneal cancer
Copyright © Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, and Michael J. Goodheart, 2011.
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Clements A, Engle D, Shelton D, Neff T, Park S, Bender D, Ahmed A, De Geest K, Button A, Engelhardt JF, Goodheart M. Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors. Proc Obstet Gynecol. 2011 Jul 28;2(1):Article 9 [2 p.]. https://doi.org/10.17077/2154-4751.1106. Free full text article.