•  
  •  
 

Abstract

Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.

Keywords

LEF-1, ovarian cancer, fallopian tube cancer, peritoneal cancer

Submission Type

Article

Rights

Copyright © Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, and Michael J. Goodheart, 2011.

Creative Commons License


This work is licensed under a Creative Commons Attribution 3.0 License.