Peer Reviewed



Patients with hereditary retinoblastoma are at increased risk for second malignancies, most notably sarcomas, particularly after treatment with radiation. Malignant phyllodes tumor is a rare secondary malignancy in these patients. We present a review of the literature and report of a patient with hereditary retinoblastoma who developed two secondary malignancies, including malignant phyllodes tumor. The patient’s phyllodes tumor presented as a palpable breast mass with suspicious findings on mammogram and ultrasound. The mass was shown to be at least a borderline phyllodes tumor via sonographic percutaneous biopsy and confirmed malignant phyllodes tumor on final surgical excision.


retinoblastoma, phyllodes, leiomyosarcoma, breast neoplasms

Total Pages


Financial Disclosure

The authors report no conflict of interest.


Copyright © Damon D. Shearer, Ryan W. Askeland, Jeong Mi Park, Laurie L. Fajardo, Limin Yang, 2013.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 3.0 License.

Available for download on 202911256274