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Patients with hereditary retinoblastoma are at increased risk for second malignancies, most notably sarcomas, particularly after treatment with radiation. Malignant phyllodes tumor is a rare secondary malignancy in these patients. We present a review of the literature and report of a patient with hereditary retinoblastoma who developed two secondary malignancies, including malignant phyllodes tumor. The patient’s phyllodes tumor presented as a palpable breast mass with suspicious findings on mammogram and ultrasound. The mass was shown to be at least a borderline phyllodes tumor via sonographic percutaneous biopsy and confirmed malignant phyllodes tumor on final surgical excision.


retinoblastoma, phyllodes, leiomyosarcoma, breast neoplasms

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The authors report no conflict of interest.


Copyright © Damon D. Shearer, Ryan W. Askeland, Jeong Mi Park, Laurie L. Fajardo, Limin Yang, 2013.

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