Effects of oral ginkgo biloba extract on pregnancy complicated by asymmetrically intrauterine growth restriction: a double-blinded randomized placebo-controlled trial

Diaa Eldeen M. Abd El Aal, Department of Obstetrics & Gynecology, Women’s Health Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
Mohammed Khairy Ali, Department of Obstetrics & Gynecology, Women’s Health Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
Ahmed Y. Shahin, Department of Obstetrics & Gynecology, Women’s Health Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
Mahmoud S. Zakherah, Department of Obstetrics & Gynecology, Women’s Health Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
Mohamad S. Abdellah, Department of Obstetrics & Gynecology, Women’s Health Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
Ahmed F. Abdel-Kawi,, Department of Obstetrics & Gynecology, Women’s Health Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
Mohamed S. Fahmy, Department of Obstetrics & Gynecology, Aswan University, Aswan, Egypt

Abstract

Objectives: to evaluate the effect of oral ginkgo biloba extract (GB)) on asymmetrical intrauterine growth restriction (IUGR).

Study Design: A randomized trial conducted at Assiut Women Health on 226 pregnant women with asymmetrical IUGR. The patients randomly received GB extract or placebo for 6 weeks. The main outcome measures were improvement in fetal weight and feto-maternal blood flow. The data were analyzed by Student’s t- test and chi-squared tests.

Result: There was a significant increase in the estimated fetal weight in the GB group (3047+ 127 gm) when compared to the placebo group (2734+ 127 gm) (p=<0.001). Moreover; there were significant increases in feto-maternal blood flow in GB group compared to the placebo group.

Conclusions: GB extract improves placental functions, Doppler indices and fetal weight in pregnancies complicated with IUGR fetuses.

 

URL

http://ir.uiowa.edu/pog_in_press/57