NLM Title Abbreviation
DOI of Published Version
Complex disorders are typically characterized by multiple phenotypes. Analyzing these phenotypes jointly is expected to be more powerful than dealing with one of them at a time. A recent approach (O'Reilly et al. 2012) is to regress the genotype at a SNP marker on multiple phenotypes and apply the proportional odds model. In the current research, we introduce an explicit expression for the score test statistic and its non-centrality parameter that determines its power. Same simulation studies as those reported in Galesloot et al. (2014) were conducted to assess its performance. We demonstrate by theoretical arguments and simulation studies that, despite its potential usefulness for multiple phenotypes, the proportional odds model method can be less powerful than regular methods for univariate traits. We also introduce an implementation of the proposed score statistic in an R package named iGasso.
Journal Article Version
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Published Article/Book Citation
PLoS One (2014) 9:9. DOI: 10.1371/journal.pone.0106918
Copyright © 2014 Kai Wang. Posted by permission.
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This work is licensed under a Creative Commons Attribution 4.0 License.