Document Type

Article

Peer Reviewed

1

Publication Date

4-11-2016

NLM Title Abbreviation

PLoS One

Journal/Book/Conference Title

PLoS One

PubMed ID

27064276

DOI of Published Version

10.1371/journal.pone.0152576

Total Pages

17

Abstract

Much of our current knowledge regarding the association of FOXP2 with speech and language development comes from singleton and small family studies where a small number of rare variants have been identified. However, neither genome-wide nor gene-specific studies have provided evidence that common polymorphisms in the gene contribute to individual differences in language development in the general population. One explanation for this inconsistency is that previous studies have been limited to relatively small samples of individuals with low language abilities, using low density gene coverage. The current study examined the association between common variants in FOXP2 and a quantitative measure of language ability in a population-based cohort of European decent (n = 812). No significant associations were found for a panel of 13 SNPs that covered the coding region of FOXP2 and extended into the promoter region. Power analyses indicated we should have been able to detect a QTL variance of 0.02 for an associated allele with MAF of 0.2 or greater with 80% power. This suggests that, if a common variant associated with language ability in this gene does exist, it is likely of small effect. Our findings lead us to conclude that while genetic variants in FOXP2 may be significant for rare forms of language impairment, they do not contribute appreciably to individual variation in the normal range as found in the general population.

Keywords

OAfund

Granting or Sponsoring Agency

National Institute on Deafness and Other Communication Disorders; National Health and Medical Research Council Centre of Research Excellence Grant

Grant Number

DC00496; DC02746; APP1023493

Journal Article Version

Version of Record

Published Article/Book Citation

Mueller KL, Murray JC, Michaelson JJ, Christiansen MH, Reilly S, Tomblin JB (2016) Common Genetic Variants in FOXP2 Are Not Associated with Individual Differences in Language Development. PLoS ONE 11(4): e0152576. doi:10.1371/journal.pone.0152576

Rights

© 2016 Mueller et al.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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URL

https://ir.uiowa.edu/comsci_pubs/4