Document Type


Date of Degree

Spring 2012

Degree Name

PhD (Doctor of Philosophy)

Degree In

Biomedical Engineering

First Advisor

Grosland, Nicole M

Second Advisor

Magnotta, Vincent A

First Committee Member

Saha, Punam K

Second Committee Member

Smucker, Joseph D

Third Committee Member

Wilder, David G

Fourth Committee Member

Wolf, Brian W


Medical imaging technologies have allowed for in vivo evaluation of the human musculoskeletal system. With advances in both medical imaging and computing, patient-specific model development of anatomic structures is becoming a reality. Three-dimensional surface models are useful for patient-specific measurements and finite element studies. Orthopaedics is closely tied to engineering in the analysis of injury mechanisms, design of implantable medical devices, and potentially in the prediction of injury. However, a disconnection exists between medical imaging and orthopaedic analysis; whereby, the ability to generate three-dimensional models from an imaging dataset is difficult, which has restricted its application to large patient populations. We have compiled image processing, image segmentation, and surface generation tools in a single software package catered specifically to image-based orthopaedic analysis. We have also optimized an automated segmentation technique to allow for high-throughput bone segmentation and developed algorithms that help to automate the cumbersome process of mesh generation in finite element analysis. We apply these tools to evaluate graft placement in anterior cruciate ligament reconstruction in a multicenter study that aims to improve the patient outcomes of those that undergo this procedure.


Anterior Cruciate Ligament Reconstruction, Bone Segmentation, Hexahedral Meshing, Image Analysis, Orthopaedic Analysis, Patient-Specific Modeling


xxv, 345 pages


Includes bibliographical references (pages 326-345).


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Copyright © 2012 Austin Jedidiah Ramme