DOI
10.17077/etd.35h55mov
Document Type
Thesis
Date of Degree
Spring 2017
Degree Name
MS (Master of Science)
Degree In
Oral Science
First Advisor
Dawson, Deborah
First Committee Member
Thalji, Ghadeer N.
Second Committee Member
Brogden, Kim A.
Third Committee Member
Stanford, Clark
Fourth Committee Member
Marek, Cindy L.
Fifth Committee Member
Holloway, Julie A.
Sixth Committee Member
Barwacz, Christopher
Abstract
Dentistry has come a long way from its humble beginnings. Like all other healthcare specialties, dentistry has evolved through the years. The understanding of physiology of dental health and disease has evolved allowing us to treat dental diseases much more efficiently. However not all dental problems are fully understood.
Diseases that affect the bone and soft tissue around teeth and dental implants, also known as “periodontal” and peri-implant” diseases respectively, have proven to be among the least understood and challenging dental diseases to treat. Recent advancements in microbiology and immunology have revealed that periodontal and peri implant disease have a plethora of interactions between the invading bacteria, the defensive human cells, and signaling micro molecules that control inflammation. Those interactions have opened up a new frontier for researchers in dentistry, microbiology, immunology, pharmacology and dental materials to understand these interactions and explore possible new treatments.
Simvastatin is a commonly prescribed drug used to control blood cholesterol. Recent research has revealed that simvastatin also possesses potent anti-inflammatory properties, and research has shown that topical application simvastatin is effective at controlling inflammation around teeth with periodontitis. However it has not yet been tested around dental implants with peri-implant disease. Thus the purpose of the current study is to investigate the effect of topical simvastatin on implants with peri-implant inflammation
Keywords
peri-implantitis, Simvastatin
Pages
xv, 123 pages
Bibliography
Includes bibliographical references (pages 111-123).
Copyright
Copyright © 2017 Ahmed Mahrous
Recommended Citation
Mahrous, Ahmed. "The use of topical subgingival application of simvastatin gel in treatment of peri implant mucisitis : A pilot study." MS (Master of Science) thesis, University of Iowa, 2017.
https://doi.org/10.17077/etd.35h55mov