Date of Degree
MS (Master of Science)
First Committee Member
Second Committee Member
Intraoperative radiation therapy (IORT) involves delivering high doses of radiation directly to tumors while sparing healthy tissues in a surgical setting. Current IORT systems lack the capability to deliver conformal radiation therapy. To overcome the limitations of non-conformal radiation therapy a collimation system is needed to conform the radiation beam to the shape of the tumor. This work presents the development of a compact collimator design intended for a scanning beam IORT (SBIORT) system. The SBIORT collimator design enables the delivery of variable square doses to the targeted region within the surgical cavity. The SBIORT collimator has a compact circular footprint of 66 mm diameter and 10 mm thickness, with a maximum aperture of 20 mm. SBIORT collimator was prototyped to validate the design in positional accuracy and dosimetry experiments. Accuracy of the collimator leaf position was ±0.25mm at a 95% confidence interval. Dosimetric evaluation revealed the collimator to have a penumbra of 1.9 mm with a leaf transmission of 0.5%. The results support the feasibility of implementing the compact SBIORT collimator design in IORT.
vii, 46 pages
Includes bibliographical references (pages 44-46).
Copyright © 2017 Brennen Neal Wears
Wears, Brennen Neal. "Development of compact collimation device for novel scanning beam low-energy intraoperative radiation therapy (SBIORT) system for pancreatic cancer." MS (Master of Science) thesis, University of Iowa, 2017.