Document Type


Date of Degree

Summer 2017

Access Restrictions

Access restricted until 08/31/2019

Degree Name

PhD (Doctor of Philosophy)

Degree In

Pharmaceutical Sciences and Experimental Therapeutics

First Advisor

Milavetz, Gary

First Committee Member

Milavetz, Gary

Second Committee Member

Murry, Daryl J.

Third Committee Member

An, Guohua

Fourth Committee Member

Brown, Timothy L.

Fifth Committee Member

Gaffney, Gary

Sixth Committee Member

Brogden, Nicole K.


The pharmacokinetics of ethanol and (-)-trans-isomer of 9-tetrahydrocannabinol (THC), and the pharmacokinetic interaction between them were characterized using statistical models in this thesis. In chapter II, a semi-mechanistic absorption rate dependent hepatic extraction model was developed to characterize ethanol pharmacokinetics. The statistical analysis conducted based on this model indicated no association between ethanol disposition and subject age or sex, and a 23% higher typical Vmax value, a 12.5% lower typical Km value for heavy drinkers compared with moderate drinkers. In chapter III, a parent-metabolite pharmacokinetic model was developed to simultaneously describe the concentration time profile of THC and its active metabolite 11-OH-THC. A parent-metabolite model with 3-compartment pharmacokinetic model for THC and a 2-compartment model for 11-OH-THC was found to best describe the pharmacokinetics of THC and 11-OH-THC simultaneously. In chapter IV, the pharmacokinetic interactions of ethanol on THC, 11-OH-THC and 11-nor-COOH-THC were evaluated using linear mixed effects models. The results suggested that co-administration of ethanol caused an increase in THC and 11-OH-THC systemic exposure, failed to influence the terminal elimination processes of THC and 11-OH-THC, and did not affect the pharmacokinetics of 11-nor-9-COOH-THC.


Ethanol, Pharmacokinetics, THC


xii, 146 pages


Includes bibliographical references (pages 142-146).


Copyright © 2017 Yu Jiang