DOI

10.17077/etd.uu3fkben

Document Type

Dissertation

Date of Degree

Summer 2016

Degree Name

PhD (Doctor of Philosophy)

Degree In

Pharmacy

First Advisor

Linnea A. Polgreen

First Committee Member

Philip M Polgreen

Second Committee Member

Joseph E Cavanaugh

Third Committee Member

Mary Schroeder

Fourth Committee Member

Bernard Sorofman

Abstract

Seasonality, or a cycling of high and low incidence, of infectious diseases has long been recognized but remains little understood. For many diseases, even major ones such as influenza, our knowledge of the seasonal drivers is very limited. One proposed driver of seasonality for many diseases is weather, especially temperature and humidity. I studied how likely an admission to a hospital was to be diagnosed with a UTI or pneumonia caused by Legionella across the US under various climates and weather conditions. I found that patients were 10–20% more likely to have a UTI when the monthly mean temperature was between 65–85°F compared to under 40°F. This may be due to slightly lower levels of hydration at warm temperatures reducing protection against UTIs. Pneumonia caused by Legionella was more common in warm (60–80°F) months than in cool or hot months. Within warm months, when humidity was above 60% there was a doubling in the odds of Legionella pneumonia. When the humidity was above 65%, the odds were quadrupled. Understanding why some diseases are seasonal and what role weather plays in this seasonality is important for both daily practice (e.g., recent weather can help diagnosis Legionella versus a more typical cause of pneumonia) and for larger policy adapting to changing weather and climate.

Keywords

climate change, legionella, legionnaires disease, temperature, Urinary tract infections, weather

Pages

xi, 165 pages

Bibliography

Includes bibliographical references (pages 153-165).

Copyright

Copyright © 2016 Jacob Edward Simmering

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