DOI

10.17077/etd.jc7b1qli

Document Type

Thesis

Date of Degree

Fall 2017

Degree Name

MS (Master of Science)

Degree In

Molecular and Cell Biology

First Advisor

Sigmund, Curt D.

First Committee Member

Quelle, Frederick W.

Second Committee Member

Grumbach, Isabella M.

Abstract

Peroxisome Proliferator-Activated Receptors (PPARs) are a family of conserved ligand activated nuclear receptor transcription factors heterogeneously expressed in mammalian tissues. PPARγ is recognized as a master regulator of adipogenesis, fatty acid metabolism, and glucose homeostasis, but genetic evidence also supports the concept that PPARγ regulates the cardiovascular system, particularly vascular function and blood pressure. There is now compelling evidence that the beneficial blood pressure lowering effects of PPARγ activation are due to its activity in vascular smooth muscle and endothelium, through its modulation of nitric oxide-dependent vasomotor function. Endothelial PPARγ regulates the production and bioavailability of nitric oxide, while PPARγ in the smooth muscle regulates the vasomotor response to nitric oxide. We recently identified retinol binding protein 7 (RBP7) as a PPARγ target gene that is specifically and selectively expressed in the endothelium. We will discuss the evidence that RBP7 is required to mediate the antioxidant effects of PPARγand mediate PPARγ target gene selectivity in the endothelium, as well as the work so far in determining the mechanism of RBP7:PPARγ interaction. (56)

Keywords

Nuclear Receptor, PPAR, Transcription

Pages

ix, 45 pages

Bibliography

Includes bibliographical references (pages 41-45).

Copyright

Copyright © 2017 Addison Wayne Woll

Included in

Cell Biology Commons

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