Date of Degree
Access restricted until 07/03/2019
MS (Master of Science)
Michael D. Henry
Sarah Celeste Vigmostad
First Committee Member
James A. Ankrum
Cancer cells traveling to distant tissues during metastasis must survive passing through the circulation. However, the influence of this fluid microenvironment on these cells is poorly understood. It was previously viewed that exposure to the hemodynamic shear forces within circulation was inhospitable to cancer cells, causing the cells to be destroyed. Recent evidence indicates that transformed cells are markedly more resistant to fluid shear stress when compared to non-transformed epithelial cells. Furthermore, these cells selectively adapt following exposure to fluid shear stresses and become more resistant to subsequent exposures to shear stress. The mechanisms behind this difference in phenotype and induced resistance are investigated. The elastic modulus, a measure of stiffness, may play a role in resistance and is shown to be altered upon exposure to fluid shear forces. Additionally, plasma membrane repair is a critical process in the resistance phenotype as cells sustain damage but are able to maintain viability. Cytoskeletal dynamics are also shown to play a role in resistance to fluid shear forces.
cancer, fluid shear stress, mechanics, repair, resistance, stiffness
x, 114 pages
Includes bibliographical references (pages 109-114).
Copyright © 2016 Benjamin Lee Krog
Krog, Benjamin Lee. "Mechanisms of resistance to fluid shear stress in malignant cells." MS (Master of Science) thesis, University of Iowa, 2016.
Available for download on Wednesday, July 03, 2019